COMPARATIVE EVALUATION OF COTTON-LIKE FIBROUS COLLAGEN HEMOSTATS MADE FROM HEAT-DEHYDRATION CROSS -LINKED COLLAGEN

概要

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We manufactured four types of cotton-like collagen hemostat which were made from atelocollagen fibers cross-linked by heat dehydration for use as topical hemostatic agents. Their fibers were 1) 15-25μm in diameter, 0.5 cm in length, 2)15-25μm in diameter, 1.0 cm in length, 3) 15-25μ m in diameter, 3.0 cm in length, and 4) 20-40μm in diameter, 3.0 cm in length. The hemostatic efficacies of these four hemostats were compared with a commercially available collagen hemostat ( Integran®) and oxycellulose ( Oxycel®) in the canine spleen under normal or low blood pressure. It was found that;type 4) and Oxycel® showed complete hemostasis under both normal and low blood pressure, and that Type 3) showed complete hemostasis only under low blood pressure. Type 4) showed higher hemostatic efficiency than Integran®or Oxycel®. The hemostasis rates of our hemostats were higher than those of Oxycel® within 3 min. after attachment of the hemostats. Tissue reaction to these collagen hemostats was minimal at two weeks after implantation.
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