EVALUATION OF HEPARIN-COATED CARDIOPULMONARY BYPASS CIRCUITS IN CORONARY BYPASS OPERATIONS.

概要

論文の詳細を見る
In the present study of one hundred patients undergoing coronary bypass, heparin-coated circuits were evaluated compared with non coated circuits. In 50 patients, heparin-coated circuits were used with initial dose of heparin 1 mg/kg (ACT>300 seconds) (group H), and 50 served as control patients with initial dose of heparin 3mg/kg (ACT>400 seconds) (group N). In the group H, the heparin and the protamine dose were reduced to a third compared with those in the group N. There was a significant decrease of platelets in the group N (p=0.001). Blood loss through chest tube drainage in the first postoperative day (360±144 for low versus 506±329 ml for full) (p=0.005) and blood transfusions (466±765 for low versus 969±1417 ml for full) (p=0.03) were significantly decreased, and the chest tubes were pulled out significantly earlier (4.0±1.1 for low versus 4.4±1.1 days for full) in the group H. The total operation time (366±64 for low versus 421±103 min for full) (p=0.002) and the operation time after the pump was stopped (125±29 for low versus 147±54 min for full) (p=0.01) were also significantly decreased in the group H. The time required for the arrest of bleeding in the group H was considered to be shortened than that in the group N.
一般社団法人日本人工臓器学会の論文