Experimental study of Tilting SAM valve in valved conduit for right ventricular outflow reconstruction

概要

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Evaluation was made of 18 mongrel dogs who underwent conduit reconstruction of the right ventricular outflow tract with woven Dacron prosthesis containing a Tilting SAM valve. This conduit was implanted as a bypass between right ventricular outflow and distal pulmonary artery by the partial clamp method. Antibiotics were given for one week after operation, but anticoagulats were not used.Eight of these animals died on the operating table, 5 as aresult of hemorrhage and 3 from sever clotting on the prosthesis. Among the 10 survivors, 9 were sacrificed after follow-up periods of one to 24 monhts for evaluation of prosthesis. In 2 dogs of them, Tilting SAM valves were found to be fixed at open position by excessive tissue growing. But in another 7 dogs, valve function was kept perfectly without over-growing tissue.Remaining one dog is living well now for 34 months after operation without identifiable evidence of valve dysfunction.These satisfactory experimental results have encouraged us to use this easily obtainable and versatile form of valved conduit in clinic.
一般社団法人日本人工臓器学会の論文