分光学的手法による膜蛋白質機能解析に関する研究
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概要
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Activity and interaction of membrane proteins, which regulates bacterial cell division, was analyzed by using various types of the spectrophotometric technique. FtsZ, which is an essential participant in prokaryotic cell division, forms a filamentous ring structure that involves GTP-dependent polymerization at the mid cell before division in Escherichia coli ( E. coli ). In E. coli, the site of cell division is known to be regulated in part by the three types of Min proteins: MinC, MinD, and MinE, which prevent the dividing site from forming at the cell pole. FtsZ and Min proteins system is essential for normal cell growth. Information about regulation mechanism of FtsZ polymerization and Min protein system should be useful for development of a new class of antibacterial drug. We have revealed Min protein system by using fluorescent polarization and FRET analysis.
- 日本膜学会の論文