連続再評価法とその周辺(I)—連続再評価法とは—
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概要
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A number of designs of phase I dose-finding trials have been developed. Algorithm-based designs such as standard 3 + 3 designs are easy to understand and implement since they do not require explicit model specification for a dose-toxicity relationship. On the other hand, model-based designs such as the continual reassessment method (CRM) (O’Quigley et al., 1990) have been proposed. The author will give a review of the CRM and its related topics. In particular, the author makes mention of some of the problems with 3 + 3 designs that have often been used in phase I dose-finding studies and gives a detailed description of ideas, concepts, theories, properties and issues in the CRM.
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関連論文
- 連続再評価法とその周辺(I)—連続再評価法とは—
- 連続再評価法とその周辺(II) : 連続再評価法の修正・拡張版と関連デザイン
- 連続再評価法とその周辺(I) : 連続再評価法とは
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