Combining Electrical Stimulation and Cisplatin Treatment Increases Caspase Activity

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概要

• 論文の詳細を見る

• Electrical stimulation has various effects on cellular functions. We previously reported a combined effect of electrical stimulation and cisplatin treatment on HeLa cell death. The present study investigates the signaling pathway behind this phenomenon. Decreased viability of HeLa cells after electrical stimulation plus cisplatin treatment was suppressed by addition of the caspase inhibitor zVAD-FMK. This showed that HeLa cell death induced by combining electrical stimulation and cisplatin treatment was caused by increased caspase activity. Moreover, mitochondrial cytochrome c release and c-Jun N-terminal kinases (JNK) activities were enhanced by this combined treatment. These results indicated that combined treatment-induced apoptosis was caused by increasing caspase activity via the JNK signal pathway.

• 公益社団法人 電気化学会の論文

著者

• KOBATAKE Eiry

  Department of Bioengineering, Tokyo Institute of Technology

• MANABE Masafumi

  Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology

• KOBATAKE Eiry

  Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology

• MIE Masayasu

  Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology

関連論文

• 細胞の増殖,分化,遺伝子発現の電気刺激による制御
• Combining Electrical Stimulation and Cisplatin Treatment Increases Caspase Activity
• A peptide release system using a photo-cleavable linker in a cell array format for cell-toxicity analysis

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