ロジウム触媒を用いる有機硫黄·リン化合物の平衡制御合成

概要

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A catalyst is a substance that changes the course of reactions without affecting the relative stability of substrates and products. The development of an efficient catalyst, which decreases the activation energy of a reaction, results in equilibrium when the relative thermodynamic stabilities of the substrates and products are close. I found that a transition-metal complex could be used as a catalyst in the synthesis and transformation of organosulfur and organophosphorus compounds, and a variety of rhodium-catalyzed reactions involving cleavage of heteroatom bonds such as C-H, C-S, C-F, S-S, P-P bonds were developed. Such single bond metathesis reactions are often under equilibrium. The control of such equilibrium to provide the desired products with high efficiency has recently become a subject of interest. I developed an equilibrium control method using co-substrates. I also developed another method, that uses thermodynamically intermediate compounds to shift equilibrium. This method using a combination of transition-metal catalysis and equilibrium control can be generally used for the synthesis of organoheteroatom compounds.