How Ablation Affected Exercise Tolerance in Patient with Long Persistent Atrial Fibrillation
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概要
- 論文の詳細を見る
Exercise intolerance is a main symptom of long-persistent atrial fibrillation (CAF). Ablation for CAF can contribute to maintaining sinus rhythm and reversing CAF-mediated remodeling. However, it remains unknown whether ablation affects exercise tolerance (ET) through the reverse remodeling.<BR><B>Methods</B><BR>For 20 consecutive CAF (>1 year) patients, ET was evaluated using a cardio-pulmonary exercise test and left atrium volume index (LAVI) was measured on echo-cardiograms. We sought to maintain sinus rhythm by pulmonary vein-isolation and ablation targeting complex fractionated atrial electroactivities with anti-arrhythmic drugs. ET and LAVI were re-evaluated after six months maintenance of sinus rhythm.<BR><B>Results</B><BR>For 19 cases, sinus rhythm was maintained regardless of the value of peak VO<SUB>2</SUB>. Peak VO<SUB>2</SUB> significantly improved from 19.3±5.0 to 23.1±5.4 ml/kg min after six months maintenance of sinus rhythm (P<0.01). LAVI significantly reduced from 30.3±8.4 to 22.2±4.5 ml/m<SUP>2</SUP> (P<0.01). However, peak VO<SUB>2</SUB> before the procedure did not predict reduction in LAVI during the follow up. Patients with higher LVEF before the procedure obtained lower improvement in peak VO<SUB>2</SUB> (r=－0.84, P<0.01). Improvement in peak VO<SUB>2</SUB> did not correlated with the reduction in LAVI, but increase in LVEF during the follow up (r=0.83; P<0.01).<BR><B>Conclusion</B><BR>Ablation contributed to improvement in the ET mainly through restoration of LVEF from the maintenance of sinus rhythm. The reverse remodeling may not be directly involved in the improvement.
- 日本不整脈学会の論文
著者
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Nakane Eisaku
Heart Center, Kitano Hospital The Tazuke Kofukai Medical Research Institute
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Inoko Moriaki
Heart Center, Kitano Hospital The Tazuke Kofukai Medical Research Institute
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Tanaka Nozomi
Heart Center, Kitano Hospital The Tazuke Kofukai Medical Research Institute
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Nohara Ryuji
Heart Center Kitano Hospital Tazuke Kofukai Medical Research Institute
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Nohara Ryuji
Heart Center, Medical Research Institute, Kitano Hospital
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Hirose Sayako
Heart Center, Medical Research Institute, Kitano Hospital
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Haruna Tetsuya
Heart Center, Medical Research Institute, Kitano Hospital
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Minamino Eri
Heart Center, Medical Research Institute, Kitano Hospital
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Inoko Moriaki
Heart Center, Medical Research Institute, Kitano Hospital
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Tanaka Nozomi
Heart Center, Medical Research Institute, Kitano Hospital
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Nakane Eisaku
Heart Center, Medical Research Institute, Kitano Hospital
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- A Potential Predictor in Reverse Remodeling after Ablation in Long-Persistent Atrial Fibrillation
- How Ablation Affected Exercise Tolerance in Patient with Long Persistent Atrial Fibrillation