Radiofrequency Ablation of Atrial Fibrillation Raises Plasma Levels of Nerve Growth Factor-beta, and Is Associated with Post-Ablation Premature Ventricular Contractions

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概要

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• <B>Introduction:</B> Nerve growth factor-β (NGF-β) expression is increased after radiofrequency ablation (RFA) in patients with atrial fibrillation (AF), indicating cardiac nerve sprouting. We investigated relationship between NGF-β levels before and after RFA and variables in Holter monitoring after RFA in AF patients. <B>Methods:</B> This study included 307 AF patients (236 men, 55.7±11.1 years, 209 paroxysmal AF) underwent RFA. Plasma levels of NGF-β were quantified before and after RFA and Holter monitoring was performed 3 months after RFA. Continuous variables were assessed using the median value as cut-off points. <B>Results:</B> NGF-β levels increased after RFA, compared to before RFA (20.98±14.24 vs. 29.57±19.47 pg/mL, p<0.001). Patients with pre-RFA NGF-β >17.20 pg/mL had higher proportions of premature ventricular contractions (PVCs) (0.06±0.36 vs. 0.01±0.09%, p=0.038) and LF/HF ratio (1.36±0.52 vs. 1.22±0.41, p=0.007) in Holter monitoring than those with ≤17.20 pg/mL. In patients without increase of NGF-β after RFA, left atrial (LA) was larger (68.3±20.2 vs. 56.9±19.0 mL, p=0.010), and LA appendage voltage (1.97±1.05 vs. 2.53±1.50 mV, p=0.028) and LF/HF ratio (1.15±0.40 vs. 1.32±0.48, p=0.020) were lower, compared to those with increase of NGF-β. <B>Conclusion:</B> Higher pre-RFA NGF-β levels were related to high frequency of PVCs and LF/HF ratio in Holter monitoring after RFA. Lower NGF-β levels were related with electroanatomical remodeling of LA, including larger LA and lower LA voltage.

著者

• PAK Hui-Nam

  Yonsei University Health System

• Joung Boyoung

  Yonsei Cardiovascular Center Yonsei University

• Lee Moon-hyoung

  Yonsei Cardiovascular Center And Cardiovascular Research

• Lee Moon-Hyoung

  Yonsei University

• Wi Jin

  Yonsei University

• Min Kim

  Yonsei University

• Pak Hui-Nam

  Yonsei University

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