The Utilization of Twelve-Lead Electrocardiography for Sudden Death after Heart Transplantation

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概要

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• <B>Background:</B> We aimed to look for the diagnostic potential of the 12-lead ECG for post-heart transplant (HTX) sudden death. <B>Methods:</B> A total of 210 patients who underwent HTX were followed at the outpatient department every month. Twelve-lead ECG was recorded on every outpatient visit. The QTc interval is calculated by Bazett's formula. Baseline (within 3 months after HTX), final (the latest 3 months or final 3 months before mortality) and mean ECG parameters were analyzed. According to the changes between the final and baseline ECG parameters, all patients were divided into five equal groups of 20% each. <B>Results:</B> Significant differences were noted between baseline and final ECG parameters in heart rate, PR interval and QRS duration (Rate 94±13 bpm vs. 92±15 bpm, p=0.014; PR interval 157±15 ms vs. 171±23 ms, p<0.001; QRS duration 95±17 ms vs. 103±21 ms, p<0.001), but not in QTc interval and frontal leads axis. During a follow-up interval of 85±53 months, sudden death happened in 24 (11%) patients. The top-20% group of heart rate increase, QTc prolongation and the right axis deviation presented a higher incidence of sudden death when compared to other four groups. The independent predictors for sudden death were a higher mean heart rate, a higher mean QTc interval, and a larger changes of QTc interval (p<0.001, 0.021, 0.006, respectively). <B>Conclusion:</B> The regular 12-lead ECG follow-up may predict post-transplant sudden death.

• 日本不整脈学会の論文

著者

• Chang Hung-yu

  Division Of Endocrinology & Metabolism Department Of Internal Medicine Chang Gung Memorial Hospi

• Chiang Meng-Cheng

  Division of Cardiology, Cheng Hsin General Hospital

• Feng An-Ning

  Division of Cardiology, Cheng Hsin General Hospital

• Yin Wei-Hsian

  Division of Cardiology, Cheng Hsin General Hospital

• Wei Jeng

  Division of Cardiology, Cheng Hsin General Hospital

• Chang Hung-Yu

  Division of Cardiology, Cheng Hsin General Hospital

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