Genetic Polymorphisms Conferring Risk of Non-Valvular Atrial Fibrillation in Korean Population: Chromosome 4q25, PITX2, and 16q22 ZFHX3
スポンサーリンク
概要
- 論文の詳細を見る
<B>Background:</B> GWAS revealed several genomes related with atrial fibrillation (AF), such as genetic variants on chromosome 4q22, PITX2, or chromosome 16q22 (ZFHX3). We evaluated those genetic polymorphisms in Korean patients with non-familial non-valvular AF. <B>Methods and Results:</B> We evaluated and compared the allelic frequencies of genetic polymorphisms of chromosome 4q22, PITX2, or 16q22 (ZFHX3) in 454 patients with non-valvular AF (296 paroxysmal AF [PAF], 158 persistent AF [PeAF]) and 422 sex-matched healthy controls by direct DNA sequencing and SNaPshotTM assay. <B>Results:</B> 1. The 4q25 rs2200733 (OR 0.368 (0.246–0.549), p<0.0001), the PITX2 rs17042171 (OR 0.368 (0.246–0.551), p<0.0001), the PITX2 rs6843082 (OR 0.234 (0.15–0.366), p<0.0001), and the 16q22 rs2106261 (OR 2.439 (1.62–3.672), p<0.0001) genotypes were more prevalent in patients with AF than control group. 2. In the haplotype analyses, the 4q25 rs17042171–rs2200733–rs6843082–rs10033464 A–T–G–G (OR 3.3421 (1.867–5.982), p<0.0001) and 4q25 without C–C–A–G (OR 4.630 (2.924–7.299), p<0.0001) were more predisposed in AF than in control group. 3. The 16q22 rs7193343–rs210626116q22 A–G haplotype was more prevalent in patients with AF (OR 0.477 (0.242–0.939), p=0.0322) than control group. <B>Conclusion:</B> This study demonstrates the Chromosom 4q25, PITX2, and 16q22 ZFHX3 polymorphisms were associated with non-familial non-valvular AF in Korean population. The 4q25 and PITX2 were closely related with Korean non-valvular AF in haplotype analyses.
著者
-
Lee Moon-Hyoung
The Depertment of EP Laboratory, Yonsei University Health System
-
Joung Boyoung
The Depertment of EP Laboratory, Yonsei University Health System
-
Jang Yangsoo
The Depertment of EP Laboratory, Yonsei University Health System
-
Kim Sook
The Depertment of EP Laboratory, Yonsei University Health System
-
Pak Hui-Nam
The Depertment of EP Laboratory, Yonsei University Health System
関連論文
- Genetic Polymorphisms Conferring Risk of Non-Valvular Atrial Fibrillation in Korean Population: Chromosome 4q25, PITX2, and 16q22 ZFHX3
- Pathophysiologic Characteristics and Clinical Outcomes of Catheter Ablation in Patients with Atrial Fibrillation Associated with Diabetes
- Frequency of Mitochondrial DNA 4977 Deletion Mutation and Their Clinical Characteristics in Patients with Atrial Fibrillation