Antitumor effect of microwave irradiation with a w/o/w hematoporphyrin derivative emulsion

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In VX2 tumor model of Japnanes white rabitts, fundamental investigation on antitumor effects of microwave irradiation with w/o/w polyhematoporphyrin ether/ester (PHE) emulsion ware carried out.The intratumoral concentration of PHE an 6 houre after local injection of w/o/w PHE emulsion (involving PHE 0.5 mg/kg) was 10.4 ± 2.4 μg/ g, and it was almost equal to the concentration after intravenous administration of PHE (2 mg/kg). On the other hand, serum concentration of PHE after local injection of w/o/w PHEE emulsion was under lomit of measuement.The reduction ratio of the tumor by microwave irradiation after administration of PHE was observed 89.8 ± 12.1 % local injection of w/o/w PHE emulsion and 77.4 ± 20.7 % in intravenous administration of PHE, respectively without hyperthermic effect caused by microwave itself. Antitumor effect was not recognized in microwave irradiation alone.In conclusion, local injection of w/o/w PHE emulsion may be beneficial as an adminitration route of PHE and microwave irradiation after PHE administration has possibility for a new treatment of superficial malignant tumors.
特定非営利活動法人 Microwave Surgery研究会の論文