Muscle Protein Metabolism during Compensatory Growth with Changing Dietary Lysine Levels from Deficient to Sufficient in Growing Rats
スポンサーリンク
概要
- 論文の詳細を見る
Livestock and laboratory animals show compensatory growth when they are fed ad libitum following a period of restriction feeding. Lysine is a major limiting essential amino acid in the diets both for humans and animals. We hypothesized that changing dietary lysine levels from deficient to sufficient induced compensatory growth in young rats. We elucidated the effect of lysine sufficiency on the dynamics of hormones, relevant to muscle protein synthesis and degradation, insulin-like growth factor-I (IGF-I) and corticosterone, and on the expression of proteolytic-related genes in skeletal muscle during compensatory growth. Lysine sufficiency where the dietary lysine level was increased from 0.46% to 1.30% after 2 wk of subjecting the rats to the lower lysine level induced 80% enhancement of growth rate of rats. During compensatory growth with the lysine sufficiency, fractional muscle protein synthesis rates were higher whereas fractional muscle protein degradation rates were lower than those of the control group (p<0.05). After lysine sufficiency, the expression of atrogin-1/MAFbx mRNA was decreased in gastrocnemius muscle (p<0.05). With the lysine sufficiency, serum IGF-I concentration increased (p<0.05) whereas serum corticosterone decreased (p<0.05). These findings suggest that compensatory growth with lysine sufficiency is due to a change of hormone levels before and after changing diets, resulting in incrementation of protein synthesis and suppression of protein degradation of skeletal muscle.
著者
-
ISHIDA Aiko
Molecular Nutrition Research Team, National Institute of Livestock and Grassland Science
-
KATSUMATA Masaya
Molecular Nutrition Research Team, National Institute of Livestock and Grassland Science
-
Nakashima Kazuki
Molecular Nutrition Research Team National Institute Of Livestock And Grassland Science
-
Ishida Aiko
Molecular Nutrition Research Team National Institute Of Livestock And Grassland Science
-
Katsumata Masaya
Molecular Nutrition Research Team National Institute Of Livestock And Grassland Science
-
KYOYA Takahito
Molecular Nutrition Research Team, National Institute of Livestock and Grassland Science
関連論文
- Effect of Orally Administered Taurine on Myofibrillar Proteolysis and Expression of Proteolytic-Related Genes of Skeletal Muscle in Chicks
- Effects of Feeding Hexane-Extracts of a Shochu Distillery By-Product on Skeletal Muscle Protein Degradation in Broiler Chicken
- AMPK Activation Stimulates Myofibrillar Protein Degradation and Expression of Atrophy-Related Ubiquitin Ligases by Increasing FOXO Transcription Factors in C2C12 Myotubes
- Changes of Serum 3-Methylhistidine Concentration and Energy-Associated Metabolites in Dairy Cows with Ketosis
- Changes in Expression of Proteolytic-Related Genes in Chick Myoblasts during Myogenesis
- Comparison of Proteolytic-Related Gene Expression in the Skeletal Muscles of Layer and Broiler Chickens
- Gene Expression of Muscle-Specific Ubiquitin Ligase, Atrogin-1/MAFbx, Positively Correlates with Skeletal Muscle Proteolysis in Food-Deprived Broiler Chickens
- The effects of concentrations of lysine in media on differentiation of 3T3-L1 preadipocytes
- Muscle Protein Metabolism during Compensatory Growth with Changing Dietary Lysine Levels from Deficient to Sufficient in Growing Rats