GH-Producing Mammary Tumors in Two Dogs with Acromegaly

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概要

• 論文の詳細を見る

• Two intact female dogs were admitted for growing mammary tumors. They had symptoms of acromegaly including weight gain, enlargement of the head, excessive skin folds, and inspiratory stridor. Serum concentrations of growth hormone (GH), insulin-like growth factor-I (IGF-I), and insulin were elevated in the two cases. From these findings, both dogs were diagnosed with acromegaly. In case 1, the GH, IGF-I, and insulin levels subsided after removal of the focal benign mammary tumors and ovariohysterectomy. In case 2, those levels subsided after removal of only focal mammary carcinoma. In both cases, immunohistochemical investigations for GH were positive in the mammary tumor cells but not in the normal mammary glands. We concluded that GH-producing mammary tumors caused the present acromegaly.

• 日本獣医学会の論文

著者

• YUKI Masashi

  Yuki Animal Hospital

• MORITA Takehito

  Laboratory of Veterinary Pathology, Faculty of Agriculture, Tottori University

• MURAI Atsuko

  Yuki Animal Hospital, 2-99 Kibacho, Minato-ku, Nagoya, Aichi 455-0021, Japan

• NISHII Naohito

  Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University

• NISHII Naohito

  Laboratory of Veterinary Pharmacotherapeutics, Tottori University, Tottori 680-8553, Japan

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