Low-Density Lipoprotein Apheresis Therapy for Steroid- and Cyclosporine-Resistant Idiopathic Membranous Nephropathy
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概要
- 論文の詳細を見る
We herein report three cases of Nephrotic Syndrome (NS) with idiopathic membranous nephropathy (IMN) in which the patients were resistant to steroid (PSL) and cyclosporine (CyA) therapy. All three patients had a high risk of renal failure because of persistently high levels of proteinuria. We performed low-density lipoprotein apheresis (LDL-A) and achieved complete remission in two cases. The third patients developed NS relapse and a deteriorating renal function; however, withdrawal from dialysis therapy was achieved. There are no proven therapies for treating patients with PSL- and CyA-resistant IMN with acute deteriorating renal function or difficulties in maintaining fluid balance. We evaluated the treatment course and physiological mechanisms and reviewed similar cases in the pertinent literature.
著者
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Nozue Tsuyoshi
Department Of Internal Medicine Yamanaka Spa Medical Center
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Sato Yoshinori
Division Of Nephrology Department Of Internal Medicine Showa University Fujigaoka Hospital
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Yoshimura Ashio
Division Of Nephrology Department Of Internal Medicine Showa University Fujigaoka Hospital
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Yoshimura Ashio
Division of Nephrology, Department of Internal Medicine, Showa University Fujigaoka Hospital, Japan
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Tsunoda Shinichiro
Division of Rheumatology, Department of Medicine, Hyogo Medical School, Japan
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Pan Qinya
Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Japan
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Wakasugi Harue
Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Japan
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Nozue Tsuyoshi
Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Japan
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