Sudden Onset Agranulocytosis and Hepatotoxicity after Taking Methimazole

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概要

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• Agranulocytosis is a rare adverse effect of methimazole. The usual duration of treatment prior to the onset of agranulocytosis is approximately 1 to 4 months, and can be as long as 1 year. Agranulocytosis together with hepatotoxicity is an extremely rare idiosyncratic side effect of methimazole treatment. We present an unprecedented case of a Grave's disease patient who showed a strong reaction to methimazole with obvious agranulocytosis and hepatotoxicity which developed only six days after administration. This case, along with a literature review, is offered with the aim to increase the awareness of physicians of sudden onset agranulocytosis and hepatotoxicity from methimazole.

著者

• Wen Ge-Bo

  Department of Metabolism & Endocrinology of the First Affiliated Hospital, University of South China, China

関連論文

• Sudden Onset Agranulocytosis and Hepatotoxicity after Taking Methimazole
• The relationship between bone marrow characteristics and the clinical prognosis of antithyroid drug-induced agranulocytosis

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