Case of Type 1 Diabetes Mellitus Following Interferon β-1a Treatment for Multiple Sclerosis
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概要
- 論文の詳細を見る
A 57-year-old woman who had been treated with interferon β-1a (IFNβ-1a) for multiple sclerosis was diagnosed with diabetic ketosis. Her fasting serum C-peptide (F-CPR) was 1.9 ng/mL and her daily urinary C-peptide (U-CPR) was 24.1 μg/day. Her anti-glutamic acid decarboxylase (GAD) antibody was 3.5 U/mL. Seven months later, she was hospitalized with body weight loss and a high level of hemoglobin A1c [11.1% (JDS)]. Her F-CPR and U-CPR were very low (0.1 ng/mL and 8.35 μg/day, respectively), and anti-GAD antibody became distinctly positive (12.4 U/mL). She had HLA-DRB1*04:05, A24, and B54. For these reasons, IFNβ-1a administration was considered a possible cause of type 1 diabetes mellitus in this case.
著者
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Yoshida Kenichi
Division Of Applied Prosthodontics Nagasaki University Graduate School Of Biomedical Sciences
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Nakamura Yoshio
Division Of Diabetes & Endocrinology Department Of Internal Medicine Hyogo Prefectural Amagasaki
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Shimodahira Makiko
Division of Diabetes and Endocrinology, Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, Japan
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Uonaga Taeko
Division of Diabetes and Endocrinology, Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, Japan
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Harada Takanari
Division of Diabetes and Endocrinology, Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, Japan
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Yoshida Kenichi
Division of Diabetes and Endocrinology, Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, Japan
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