Recovery of Kidney Function by Rituximab-based Therapy in a Patient with Waldenström's Macroglobulinemia-related Nephropathy Presenting Cast Nephropathy and Interstitial Lymphocytic Infiltration

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概要

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• A 60-year-old man with Waldenström's macroglobulinemia (WM) was admitted to our hospital for evaluation of rapid progressive renal deterioration despite 3 cycles of oral melphalan and prednisolone (MP) therapy. Renal biopsy just before introducing hemodialysis revealed cast nephropathy and severe tubulo-interstitial infiltration of B lymphocytes. After 6 cycles of rituximab, cyclophosphamide, vincristine and prednisolone (R-COP) therapy, his renal function improved enough to discontinue hemodialysis. This is a rare case of WM-related renal involvement caused by both monoclonal protein and tumor infiltration and, to our knowledge, the second report on improved renal function by rituximab-based therapy.

著者

• Shigeno Kazuyuki

  Internal Medicine III, Division of Hematology, Hamamatsu University School of Medicine, Japan

• Sakao Yukitoshi

  Internal Medicine I, Division of Nephrology, Hamamatsu University School of Medicine, Japan

• Ono Masafumi

  Internal Medicine I, Division of Nephrology, Hamamatsu University School of Medicine, Japan

• Nakamura Satoki

  Internal Medicine III, Division of Hematology, Hamamatsu University School of Medicine, Japan

関連論文

• Recovery of Kidney Function by Rituximab-based Therapy in a Patient with Waldenström's Macroglobulinemia-related Nephropathy Presenting Cast Nephropathy and Interstitial Lymphocytic Infiltration

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