Cyclosporine A and Reduced-intensity Conditioning Allogeneic Stem Cell Transplantation for Relapsed Angioimmunoblastic T cell Lymphoma with Hemophagocytic Syndrome

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概要

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• No standard therapeutic approaches have so far been established for the treatment of relapsed angioimmunoblastic T-cell lymphoma (AITL), a subtype of non-Hodgkin lymphoma. This case report describes an AITL patient who relapsed with hemophagocytic syndrome (HPS) two months after receiving high-dose chemotherapy (HDCT) supported by autologous peripheral blood stem cell transplantation (PBSCT). The patient was successfully treated with cyclosporine A (CsA) and subsequent allogeneic PBSCT with reduced intensity conditioning regimen (RIST). RIST may deserve consideration for treatment of AITL patients with severe complications such as HPS. Additionally, CsA could be a less-toxic therapeutic option for pre-RIST induction therapy against AITL.

著者

• Kuroda Junya

  Division Of Hematology And Oncology Department Of Medicine Kyoto Prefectural University Of Medicine

• Horiike Shigeo

  Division Of Hematology And Oncology Department Of Medicine Kyoto Prefectural University Of Medicine

• MATSUMOTO Yosuke

  Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicin

• Shimura Yuji

  Division Of Hematology And Oncology Department Of Medicine Kyoto Prefectural University Of Medicine

• Kobayashi Tsutomu

  Division Of Hematology And Oncology Department Of Medicine Kyoto Prefectural University Of Medicine

• Kiyota Miki

  Division Of Hematology And Oncology Department Of Medicine Kyoto Prefectural University Of Medicine

• Taniwaki Masafumi

  Division Of Hematology And Oncology Department Of Internal Medicine St. Marianna University School O

• Shimura Yuji

  Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan

• Matsumura Yayoi

  Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan

• Yamamoto-Sugitani Mio

  Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan

• Kuroda Junya

  Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan

• Kiyota Miki

  Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan

• Matsumoto Yosuke

  Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan

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