Long-term Survival in Metastatic Malignant Melanoma: Ipilimumab Followed by Vemurafenib in a Patient with Brain Metastasis

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概要

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• A 46-year-old man was diagnosed with brain metastasis after a two-year history of melanoma. Paliative radiotherapy was administered followed by dacarbazine, temozolamide, ipilimumab, stereotactic radiosurgery, ipilimumab reinduction and finally vemurafenib, to which the patient showed objective responses. The patient received vemurafenib for four months and died after progresive disease. Long-term follow-ups after surgery have been reported in the literature. However, in patients with unresectable metastases, outcomes are mostly detrimental. The present patient survived for 40 months after brain metastasis. The unusually long survival observed in the present case indicates the sequential effectiveness of radiotherapy, chemotherapy, ipilimumab, stereotactic radiosurgery and vemurafenib.

著者

• Sevinc Alper

  Departments of Medical Oncology, Gaziantep Oncology Hospital, Gaziantep University, School of Medici

• Balakan Ozan

  Department Of Internal Medicine Sutcu Imam University Medical Faculty

• Balakan Ozan

  Department of Medical Oncology, School of Medicine, Gaziantep University, Turkey

• Süner Ali

  Department of Medical Oncology, School of Medicine, Gaziantep University, Turkey

• Yiğiter Remzi

  Department of Neurology, School of Medicine, Gaziantep University, Turkey

• Balakan Tuba

  Department of Radiology, Avukat Cengiz Gokcek State Hospital, Turkey

• irikçi Akif

  Department of Radiology, School of Medicine, Gaziantep University, Turkey

• Sevinç Alper

  Department of Medical Oncology, School of Medicine, Gaziantep University, Turkey

関連論文

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• Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome and adult onset Still's disease : case report and review of the literature
• Long-term Survival in Metastatic Malignant Melanoma: Ipilimumab Followed by Vemurafenib in a Patient with Brain Metastasis

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