Gefitinib for a Poor Performance Status Patient with Squamous Cell Carcinoma of the Lung Harboring EGFR Mutation

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概要

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• Recent reports have shown gefitinib, epidermal growth factor tyrosine kinase inhibitor (EGFR-TKI) induced marked improvement in ECOG performance status (PS) as first-line therapy in EGFR mutation-positive patients with extremely poor PS. EGFR mutations frequently occur in east-Asian, female, non-smoking, adenocarcinoma patients, however they are occasionally detected in patients with non-adenocarcinomas or with a heavy smoking history. We describe a case in which EGFR mutation was detected in a male, current smoker, squamous cell carcinoma (SCC) patient with PS 4, who showed a marked response to the first-line gefitinib therapy. EGFR mutational analysis is recommended even for SCC patients especially in east-Asian populations.

著者

• Kida Yoko

  Department of Respiratory Medicine, Kobe City Medical Center West Hospital, Japan

• Imai Yukihiro

  Department of Clinical Pathology, Kobe City Medical Center General Hospital, Japan

関連論文

• Gefitinib for a Poor Performance Status Patient with Squamous Cell Carcinoma of the Lung Harboring EGFR Mutation
• Association of Hyperglycemia on Admission and During Hospitalization with Mortality in Diabetic Patients Admitted for Pneumonia

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