Adult-onset Still's Disease Complicated by Autoimmune Hepatitis: Successful Treatment with Infliximab
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概要
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A 17-year-old woman was previously diagnosed with autoimmune hepatitis (AIH) by liver biopsy. Adult-onset Still's disease (AOSD) was subsequently diagnosed on the basis of high fever, arthralgia, erythema, leukocytosis (>80% granulocytes), cervical lymph node swelling, splenomegaly, and hyperferritinemia. Her symptoms and liver dysfunction improved with prednisolone of 60 mg daily and subsequently methotrexate was added. However her symptoms and liver dysfunction relapsed when prednisolone was tapered to 20 mg/day. Therefore infliximab was introduced additionally and her symptoms and liver dysfunction subsided. To our knowledge, this is the first reported case of AOSD with AIH diagnosed by liver biopsy.
著者
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Koyama Yoshinobu
Center For Rheumatic Diseases Iizuka Hospital
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FUJII Kenji
Center for Rheumatic Disease, Iizuka Hospital
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OSUGI Yasuhiro
Center for Rheumatic Disease, Iizuka Hospital
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Fujii Kenji
Center for Rheumatic Disease, Iizuka Hospital, Japan
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Rokutanda Ryo
Center for Rheumatic Disease, Iizuka Hospital, Japan
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Ota Toshiyuki
Center for Rheumatic Disease, Iizuka Hospital, Japan
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KOYAMA Yoshinobu
Center for Rheumatic Disease, Iizuka Hospital
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Koyama Yoshinobu
Center for Rheumatic Disease, Iizuka Hospital, Japan
関連論文
- Etanercept in combination with conventional disease-modifying antirheumatic drugs (DMARDs) in the treatment of rheumatoid arthritis patients intolerant to methotrexate
- Adult-onset Still's Disease Complicated by Autoimmune Hepatitis: Successful Treatment with Infliximab
- A concomitant case of giant cell arteritis and microscopic polyangiitis with hemoperitoneum by rupture of the gastroepiploic artery