Expression of Proliferating Cell Nuclear Antigen in Normal Oral Mucosa, Oral Submucous Fibrosis and Leukoplakia with or without Dysplasia
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概要
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Proliferating cell nuclear antigen (PCNA), which is also known as cyclin, is an intranuclear polypeptide of 36 kDa that shows peak synthesis during the S-phase of the cell cycle. PCNA is an auxiliary component of DNA polymerase- and appears in all proliferating cells. It plays an important role in DNA synthesis, DNA repair, cell cycle progression and cell proliferation. PCNA is a marker of proliferation and may prove to be a useful objective indicator of the biological behavior of various tumors. Increased PCNA expression is observed as tissue progresses from normal epithelium to hyperplasia, to dysplasia and to squamous cell carcinoma. The aim of this study was to focus on the expression of PCNA in normal oral mucosa (NOM), leukoplakia with or without dysplasia and oral submucous fibrosis (OSF) and to investigate the effects of PCNA on oral epithelium due to long-term exposure. PCNA expression in NOM was significantly lower than that in leukoplakia with or without dysplasia and OSF, while PCNA expression in leukoplakia with epithelial dysplasia was significantly higher than that in leukoplakia without dysplasia. However, there were no significant differences between OSF and leukoplakia without dysplasia. In addition, greater durations of habitual areca quid chewing and tobacco smoking were associated with greater PCNA activity in the oral mucosa. The reasons for high expression of PCNA in leukoplakia with dysplasia, OSF and leukoplakia without dysplasia are unclear, but may be related to cell proliferation and unscheduled DNA synthesis or induction by the presence of tumor cells or growth factors.
- 日本大学松戸歯学部 口腔科学研究所の論文
著者
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Kaur Mandeep
Indira Gandhi Govt Dental College
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Saxena Susmita
Subharti Dental College
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Bansal Puja
Hindustan Dental College