Intravenous Single-Injection Study of Thymoxamine Hydrochloride in Healthy Volunteers

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The pharmacokinetics, pharmacodynamics and safety of thymoxamine were studied in 3 healthy male subjects by intravenous injection of thymoxamine hy drochloride at doses of 2, 5 and 10mg. Each subject recieved one dose at each level, the amount increasing with each week's injection.<BR>Each subject rested in supine position on the examination bed while the fol lowing parameters were continuously monitored for 2-3 hours: systolic blood pressure ; deep body temperature at the forehead, palm and sole ; fingertip skin temperature ; blood flow in the skin at the wrist ; ECG ; and respiratory rate.<BR>Thymoxamine tended to lower the blood pressure and elevate the peripheral temperature. Some subjects had a warm feeling at the extremities and flushed feeling at the cheeks.<BR>The ECG and the respiratory rate showed no significant change. The half time of this drug was found to be 83 min. The urinary excretion rate was 20.3% within 24 hours. The feces excretion rate was 2.0% within 72 hours. No side effect noted in laboratory tests were observed during this study.
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