Clinical Efficacy of Furosemide-Retard (Hoe 058 R) in Essential Hypertension : ADouble-Blind Controlled Study with Trichlormethiazide

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概要

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• The antihypertensive effect and usefulness of Hos 058 R (H) were compared with those of trichlormethiazide (T) as a control drug under double-blind conditions.<BR>The following results were obtained.<BR>1. Antihypertensive effect<BR>There was no significant difference between Hoe 058 R and trichlormethiazide in the global evaluation of antihypertensive effect. The effects on both systolic and mean blood pressure were significantly greater with T than with II However, there was no significant difference in the effect on diastolic pressure.<BR>2. Laboratory data<BR>The decrease in the serum Cl- level in 8th week was significantly greater in the T-group than in the H-group.The BUN elevation in the T-group was significantly higher than in the H-group.<BR>3. Side effects<BR>The incidence of pollakiuria and polyuria was 7.1% (6/85) in the H-group and 3.7% (3/82) in the T-group.This difference was not significant. No other note-worthy side effects occurred.<BR>4. Usefulness<BR>There was no significant difference between the two groups.

著者

• 前田 貞亮

  関東労災病院

• 横田 修

  Dept. of Internal Medicine, Omiya Red Cross Hospital

• 海老原 昭夫

  Dept. of Clinical Pharmacology, School of Medicine, Jichi Medical School

• 増山 善明

  Dept. of Circulation, Wakayama Medical College

• 越川 昭三

  Dept. of Internal Medicine, Fujigaoka Hospital of Showa University

• 三条 貞三

  Dept. of Internal Medicine, Tokyo Teishin Hospital

• 永井 恒司

  Dept. of Pharmacy, Hoshi Pharmaceutical College

• 伊東 貞三

  Dept. of Circulation, Self-Defense Forces Central Hospital

• 池田 隆夫

  Dept. of Internol Medicine, Kanto Teishin Hospital

• 石田 尚志

  1st. Dept. of Internal Medicine, St. Marianna Ika Daigaku

• 糸川 正

  2nd. Dept. of Internal Medicine, School of Medicine, Showa University

• 小出 桂三

  Dept. of Circulation, National Oji Hospital

• 坂田 徹吾

  Dept. of Internal Medicine, Tokyo Rosai Hospital

• 笹岡 拓雄

  Dept. of Internal Medicine, Yokosuka Kyosai Hospital

• 柴恒 昌功

  Dept. of Internal Medicine, Kawasaki Municipal Ida Hospital

• 柴田 俊郎

  Dept. of Internal Medicine, Hitachi Seisakusho Totsuka Hospital

• 瀬田 克孝

  Dept. of Internal Medicine, Central Hospital of Health Insurance

• 田中 政

  2nd. Dept. of Circulation, Japanese Red Cross Medical Center

• 高橋 政夫

  Dept. of Internal Medicine, Omori Red Cross Hospital

• 原田 敏雄

  Dept. of Internal Medicine, Kodaira Memorial Hitachi Hospital

• 日高 三郎

  Dept. of Internal Medicine, Kawakita Hospital

• 藤森 一平

  Dept. of Internal Medicine, Kawasaki Municipal City Kawasaki Hospital

• 山形 陽

  Dept. of Nephrology, Hitachi General Hospital

• 山根 至二

  Dept. of Internal Medicine, Tokyo Kosei Nenkin Hospital

• 前田 貞亮

  関東労災病院内科

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