Clinical Effects of Trapidil on Angina Pectoris with Special:Reference to Exercise Tolerance Estimated by Multistage Treadmill Exercise

概要

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This study was carried out to investigate effects of trapidil on subjective symptoms, electrocardiograms and, especially, exercise tolerance of patients with angina pectoris. The material consisted of 8 male patients with angina of effort, aged from 46 to 73 years. Trapidil was administered in a dose of 100 mg, 3 times, namely, after each meal, daily for 2 to 13 weeks. The multistage treadmill exercise tests based on modified Bruce's protocol was performed before and after trapidil. The end-point of exercise was anginal pain. Beneficial effects on anginal attack, exercise-induced ST-T changes and exercise tolerance were obtained in 75.0%, 71.4% and 28.6% of the material, respectively. The duration of exercise after trapidil (mean value: 5.21 min.) was significantly (P<0.05) increased as compared with that before trapidil (mean value: 6.14 min.). No significant changes were observed in heart rates, arterial blood pressures and pressure rate products when those values before, during and after exercise were compared. Noside effects occurred in all cases. It was concluded that trapidil was effective inthe treatment of angina pectoris.
一般社団法人日本臨床薬理学会の論文