Spectral EEG analysis in evaluation of the effects of 4-(O-benzylphenoxy)-N-methylbutylamine hydrochloride (E-0687) in patients with cerebrovascular disease.:Patients with Cerebrovascular Disease

概要

論文の詳細を見る
The efficacy of E-0687 on the power spectrum of EEG was quantitatively evaluated in nine patients exhibiting chronic cerebrovascular disease.<BR>The power spectrum arrays were used to evaluate the stability of EEG activitieswithin all recording periods. EEG topographies were made for visual evaluation ofthe EEG changes in each patient. For quantification of the EEG power, five channels (F7, F8, T5, T6, Fz) and nine frequency bands were selected, and the EEGpowers and % powers of each band on each channel were calculated. The effects of E-0687 were revealed as a tendency to decrease in both power and % power of the delta and beta frequency bands, and to increase in the same indices of the theta andalpha bands. Statistical significance was detected in the rate of increase in % powerof the alpha bands on the leads of the non-affected sides, and in the rate of decreasein the same indices of the beta bands on the leads of both the affected and nonaffected sides. The efficacy of this drug on the non-affected side tended to be higherthan on the affected sides. These results were discussed comparing with results ofsome reported animal examinations.
一般社団法人日本臨床薬理学会の論文