The Effect of L-DOPA on the treatment of Hemiplegia of Cerebrovascular diseases

概要

論文の詳細を見る
The effect of L-DOPA was examined in 25 patients suffering from hemiplegia of cerebrovascular diseases. Before and after giving L-DOPA at dose levels of 1-3 g for one month, we checked the muscle strength, ROM and ADL (especially ability of gait and skill of the affected limb), sense, speech function of the patients with aphasia and dysrythmia by the Shuell-Sasanuma speech test, and mental faculties by the WAIS mental test.<BR>Eight patients showed diminished tonus of the muscles of affected extremities. Four patients experienced moderate relief of dysesthetic pain in stiff muscles. Sensory examination did not reveal any improvement in their sensory disturbance. L-DOPA failed to show any discernible effect on aphasia or any usefulness in improving intellect. A patient with dysrythmia came to be able to speak clearly and smoothly.<BR>Side effects were observed at dose levels over 1.25 g in some cases. The severe side effects were vomiting, weakness, and lack of volition.<BR>In conclusion, L-DOPA did not show any remarkable effect on the treatment of hemiplegia, but eight patients with rigidity in their affected extremities showed subjective improvement in their disability at dose levels over lg.
一般社団法人日本臨床薬理学会の論文