Genetic Polymorphism of N-acetylation of Isoniazid with Non-insulin-dependent diabeters Mellitus Patients in Japanese.

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概要

• 論文の詳細を見る

• 1. Determination of isoniazid acetylation phenotype was carried out in 213 Japanese patients with pulmonary tuberculosis (control group) and 52 Japanese patients with both non-insulin-dependent diabetes mellitus and pulmonary tuberculosis (NIDDM group). 2. Distribution of the log (INH/AcINH) ratio of the Japanese population was observed in the two groups. 3. Assuming an antimode of 0.6, the proportion of slow acetylators was found to be 10.0% in Japanese pulmonary tuberculosis patients, and 3.6% in Japanese NIDDM patients with pulmonary tuberculosis. These differences were not significant statistically.

著者

• Kubo Hiroaki

  Pharmaceutics Research Laboratory Tanabe Seiyaku Co. Ltd.

• TAKADA ATSUSHI

  Pharmaceutical Institute, School of Medicine, Keio University

• FURUKAWA Kouichi

  Pharmaceutical Division, National Tokyo Chest Hospital

• KOHNO Haruichi

  Pharmaceutical Division, National Tokyo Chest Hospital

• KUBO Hiroaki

  Pharmaceutical Sciences, Kitasato University

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• Genetic Polymorphism of N-acetylation of Isoniazid with Non-insulin-dependent diabeters Mellitus Patients in Japanese.

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