加齢時のSHRの血圧およびリポパ-オキサイドに対する温泉浴の作用効果
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To find the effects of habitual hot-spring bathing from a young age on the blood pressure of adults, the effects of hot-spring bathing on lowering blood pressure and serum lipoperoxides were investigated using spontaneously hypertensive rats (SHR). Male SHRs, six week old, were subjected to hot bathing at 40°C for 10min per day for 14 weeks continuously.1) Hot bathing tended to suppress blood pressure. For hot-spring bathing, blood pressure was maintained within 100 to 120mmHg until the end of the bathing experiment. Furthermore, these controlled values of blood pressure were maintained for more than 5 weeks after cessation of the experiment. For plain-water bathing, blood pressure increased gradually, but then was maintained within 100 to 145mmHg until the end of the experiment. These values were maintained for 4 weeks after cessation of the bathing experiment. In those SHRs that were not subjected to bathing, blood pressure was 100mmHg at the age of 6 weeks, 150mmHg at the age of 13 weeks, 160mmHg at the age of 19 weeks, and 170mmHg at the age of 24 weeks. Accordingly, it was found that hot-spring bathing is more effective than plain-water ordinary bathing in suppressing blood pressure.2) The serum lipoperoxide values decreased during the 12th week of the bathing experiment. These values remained at a significantly low level until the end of the 6th week after cessation of the bathing experiment. This finding seems to suggest that habitual bathing from a young age may slow down the aging process.3) It was shown that the concentrations of catecholamines in blood were lower in both the hot-spring bathing group and the plain-water bathing group than those in the non-bathing group. This may indicate that controlled secretion of catecholamines is related to the relaxation induced by bathing.4) The rate of weight increase was significantly lower in the groups of SHRs subjected to hot-spring bathing and plain-water bathing from a young age than in the non-bathing group.
- 一般社団法人 日本温泉気候物理医学会の論文
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