Coloring of Urine by Phenothiazine Derivatives

概要

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Patients treated with Protizinic acid, one of the phenothiazine derivatives, found that their urine turned blue when it was mixed with tap water and reported this to the doctors, being worried about the unexpected phenomena. The refore the cause of this phenomena was examined. The color reaction of such phenothiazines as Chlorpromazine HC1 (Cp), Dimetotiazine (Dm), Protizinic acid (Pt), Promethazine HCl (Pm) and Metiazinicacid (Mt) to alkaline and acid reagents, purified water and tap water was examined. The pH of discoloring point was also determined by adding NaOH to test solutions which had been previously colored by HClO4. It was found that Pt and Mt solutions turned blue when mixed with tap water but had no color change when mixed with purified water. This color change was especially marked with Pt. The color substance in the Pt-HClO4 solution was not extractable by ether. The difference between tap water and purified water in the color reaction may be attributable to residual content of chlorine and iron ions in the tap water.
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