微温長時間浴による血漿レニン活性の低下-1-基礎的研究

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It has been reported that thermoneutral (34.5°C) water immersion (WI) up to the neck causes remarkable natriuresis and suppression of plasma renin activity (PRA), however the mechanism is not fully understood.This present study consists of three experiments comparing the effect of WI in seated posture for 60-90min. with that of sitting posture in the air (Exp. 1); with that of WI in supine posture (Exp. 2); and with that of cold (25.0°C) immersion for 10min. (Exp. 3).Subjects were all healthy young men aged 20-25.The room temperature was 27-29°C.On Fig. 1 it can be seen that the suppression of PRA by WI was significant as compared with the preimmersion condition, while no significant change was observed in the control study.The suppression of PRA in Exp. 2 was observed to be almost equal whether in the supine posture or seated.On Fig. 3 the levels of PRA rapidly decreased with cold water immersion. The percent decrease of PRA both immersions were correlated (r=0.69, p<0.05) for this figure.From these data, it is postulated that suppression of PRA by thermoneutral water immersion was modified by the posture during immersion. This suggests we should take into consideration neurotic factors in PRA suppression other than just hydrostatic pressure and resulting increase in central blood volume.
一般社団法人日本温泉気候物理医学会の論文