Effects of TRH-tartrate on Anterior Pituitary Hormone Release in Men
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The effects of TRH-tartrate (TRH-T), a synthetic TRH analogue, on anterior pituitary hormone release were investigated in 10 normal male adults. In addition, the physical and laboratory findings were examined before and after TRH-T administration to check its side effects.<BR>The intravenous administration of 500μg TRH-T stimulated TSH secretionfollowed by the increase of thyroid hormone (T<SUB>3</SUB> and T<SUB>4</SUB>) release in all subjects. The peak levels of plasma TSH were observed between 15 and 30 min after the injec tion with the values of 12.5±1.48μU/ml<BR>Plasma prolactin levels reached to the maximum (12.7±1.72 ng/ml) about 15 min earlier than TSH peak levels.<BR>Plasma GH and LH levels in response to TRH-T were increased in some cases and plasma FSH and cortisol did not show any significant changes after the injection.<BR>No significant side effects were observed in view of physical and laboratory findings in all subjects who were examined before and after TRH-T administration.<BR>These results indicate that TRH-T is a useful tool for testing pituitary reserves of TSH and prolactin, since it posesses a stimulating effect on the hormone release without any significant side effects.