ACTH-Testに関する臨床知見補遺
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概要
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I have investigated the effects of hot spring bath on pituitary adrenocortical function in healthy or injured rats using eosinopenic response to bath.1) The repeated baths were given to healthy rats three times daily for six days in three different hot springs and plain water. Changes in the eosinophil count after bathing followed a definite pattern. On the second day or fourth day no remarkable change was shown, however, on the seventh day the number of circulating eosinophils was found either to be falling or to have fallen to low or zero values and the eosinopenia was maintained for about two weeks. The highest eosinopenic state occured on the seventh day after the bath had finished. In acid or "Manjuyu" spring bath which are both hydrogen sulphide springs the duration of eosinopenia was longer than in muriated spring or plain water bath and in the rats bathed in acid or "Manjuyu" spring a decrease of the body weight was recognized.2) A single bath was performed in two ways: healthy rats were bathed in acid or muriated spring and injured rats in acid spring. In these cases the change of the eosinophil count after hot spring bath was compared with corresponding results after plain water bath or without it. In healthy rats no remarkable change was shown in the eosinophil count. However, in injured rats the various differences of the change were recognized after hot spring bath. When phenobarbital, magnesium sulphate, pilocarpin, vagostigmin had been injected or an adrenal had been excised, a marked fall in the eosinophils was recognized after hot spring bath. On the contrary when ephedrin or histamin had been injected the degree of the eosinophil depression by their medicaments was decreased. When Coramin had been injected no different change was produced in eosinophil count after hot spring bath and when adrenalin or acetylcholin had been injected no definite tendency was shown after hot spring or plain water bath.From these experimental results I can conclude that pituitary adrenocortical hyperactivity occurs by the proper use of hot spring bath cure and these actions of hot spring are not similar in different hot springs and the effects of hot spring bath on patuitary adrenocortical function are remarkably different between in healthy and in injured animals. When adrenocortical failure is present, central nervous system are injured or parasympathetic nervous system are stimulated the hyperactivity of pituitary adrenocortex by hot spring bath is increased.
- 一般社団法人 日本温泉気候物理医学会の論文