珪酸と動脈硬化症との関係についての実験的研究
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Since cholesterol induced atherosclerosis was first produced by Anitchkow in the rabbit, lipid deposits in the arterial wall had generally been admitted as an early change of arteriosclerosis.Recently, Akiya and Misawa suggested that there might be some relation between the development of arteriosclerosis or hypertension and much intake of silicic acid contained excessively in drinking water and grain. Also, it was stated that Arimoto had produced atherosclerosis and coronary arteriosclerosis accompanied with no lipid deposits by the administration of sodium silicate peritoneally in the rabbits.Therefore, the author performed following experiments to clarify how the repeated and excessive administration of silicate could influence upon the development of arteriosclerosis and the disturbance of lipid metabolism in the blood.Twenty male white Leghorn cockerels (2 months old) were divided into following 4 groups and fed by a commercial chick mash (bog/day) and autopsied after 6 weeks of the experiments: A group (control) was fed only with the mash, B group with the mash added cholesterol (1g/day), C group with the mash and sodium silicate (1g/day), D group with the mash and cholesterol (1g/day) plus sodium silicate (1g/day).The aorta divided into ascending, thoracic and abdominal portions and the arterioles of the other organs (heart, kidney, liver, spleen and lung) were investigated histologically.Serum total cholesterol, β-lipoprotein, triglyceride, NEFA and uric acid were measured.And following results were obtained.1) Although serum total cholesterol and β-lipoprotein changes before and after the experiment among the 4 groups showed no significant difference, it was suggested that the administration of silicate might promote the disturbance of cholesterol and β-lipoprotein metabolism in the blood so that a tendency was shown that these levels in the C group increased more than in the A group and the changes in the D group more than in the B group. But a significant difference was proved only between the A group and the B group or the D group in β-lipoprotein.2) Triglyceride and NEFA showed no significant difference by the experiment among the 4 groups.3) The rate of positive Sudan III stain of the ascending aorta was as follows: 0% in the A group, 100% in the B group, 40% in the C group and 40% in the D group.Therefore, the administration of silicate was likely to promote lipid deposits in the ascending aorta.4) There was a significant difference in serum total cholesterol or β-lipoprotein between the lipid deposits positive and negative groups, but no significant difference in triglyceride or NEFA was proved between the both groups.5) The percentage of the positive findings of intimal cell proliferation in the thoracic aorta was 20% in the A group, 60% in the B group, 60% in the C group, 40% in the D group.Therefore, it was suggested that silicate promoted the development of thoracic atherosclerosis judged by the intimal cell proliferation and lipid deposits.6) Diffuse fibrous intimal thickening of the abdominal aorta could be explained by naturally occurring atherosclerosis as the change was observed in the majority of the cases (19 in 20 cases) unrelated to the group classification.7) Abnormal changes of the arterioles in the other organs were not proved and also no amyloidosis was shown in the kidney.8) There was no significant difference among the 4 groups in serum uric acid level.
- 一般社団法人 日本温泉気候物理医学会の論文