小児気管支喘息と気象との関係--人工気象室を利用して
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概要
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It is well known clinical fact that weather change may precipitate the onset symptoms in patients with bronchial asthma, arthritis, etc.There are many reports, analysing a weather chart, that the frequency of asthmatic attack is related to meterologic changes.In this report, it is discussed whether climatic factors which are purely created in the Controlled Climate Chamber affect the lung function (forced expiratory volume in one second-FEV1), serum cotisol levels, and serum cyclic-3′5′-adenocine monophosphate (c-AMP) levels in asthmatic children.The subjects for this study were 64 patients with childhood asthma who had no asthmatic symptoms at the time of the study. Patients were entered to the Controlled Climate Chamber which was automatically controlled as following programs, 1, gradual drop of temperature from room temperature (25°C) to 5°C over 60min (A group), 2, temperature pre-set at 5°C (B group), 3, gradual decrease of 50mb in atmospheric pressure (C group), 4, increase of 50mb over 60min followed by steady state for 30min (D group). Conditions in the Controlled Climate Chamber for controll group were mainteined in the same temperature and pressure are those of outside the chamber on the same day. All procedures were performed during from 12.45p.m. to 14.15p.m..The FEV1 was measured before and immediately, 5min, 15min, 30min, 60min, and 90min after entry to the chamber.Also venopunctures were done before and after 90min to measure the serum cortisol and serum c-AMP levels.Slight but not statistically significant decrease of FEV1 was observed in A group. In B group, significant decrease of FEV1 was observed immediately after, and at 5min, 15min after entry. Slight decrease without statistical significance were observed after 60min and 90min.In C group, significant decrease of FEV1 was observed only at 90min. At other times, the decrease was not significant.On the other hand, striking increase of FEV1 was observed at all the time in D group.Simultaneously measured serum cortisol level showed slight decrease without statistical significance in all groups.The changes of c-AMP level did not show any constant tendency in all groups.These results suggest that cold climate and low barometric pressure may induce the decrease of lung function in patient with childhood asthma and high barometric pressure certainly induce improvement of lung function. The change of serum cortisol level and c-AMP level showed variable tendencies. It is speculated that more distinct change may be obtained, if the samples for evaluation of serum cortisol and c-AMP level are obtained earlier the 90min after entry to the chamber.
- 一般社団法人 日本温泉気候物理医学会の論文