Effects of Trimebutine on Human Gastrointestinal Tract Motility (I):A Double-blind Cross-over Study

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The effect of trimebutine on the digestive tract motility was studied in 4 healthy male volunteers by means of a crossover technique under the double-blind condition. The subjects were administered each dose of trimebutine 0, 100, 200 and 300mg in randomly assigned order, respectively on different days. An X-ray study was performed to evaluate the effect of trimebutine on gastric emptying time, gastric motility and intestinal transit time.<BR>The results obtained were as follows: <BR>1) Gastric emptying time showed a dose dependent increasing tendency and statistical significance was observed in the case given 200 mg or 300 mg of trimebutine in comparison with the case of 0 mg.<BR>2) No influence of trimebutine on gastric tonus and gastric peristalsis was observed<BR>3) Intestinal transit time tended to be slightly shorten, irrespective as to wheather it is due to direct or secondary effect of the drug.
一般社団法人日本臨床薬理学会の論文