THE EFFECTS OF FLAVOXATE HYDROCHLORIDE ON THE GASTROINTESTINAL MOTILITY

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概要

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• The experiments were performed to study the effects of Flavoxate Hydrochloride on the gastrointestinal motility and its underlying mechanism.<BR>Gastrointestinal motility was inhibited at first and then accelerated markedly after the intranveous injection of Flavoxate hydrochloride (10mg/kg) in the experiments of anesthetized dogs. For analyzing the underlying mechanism of this response the following experiments were executed.<BR>1) The pendular movements of isolated ileum of rabbits were accelerated with administration of low concentration of Flavoxate hydrochloride less than 10<SUP>-5</SUP>g/ml, while these were reduced with administration of high concentration more than 10<SUP>-4</SUP>g/ml. Because the tetrodotoxin (2.5×10<SUP>-7</SUP> g/ml) has no essential effect on this responses, it could be postulated that Flavoxate Hydrochloride has direct effect on intestinal smooth muscle itself.<BR>2) Flavoxate hydrochloride (10mg/kg) induced the differentiated regional response of the sympathetic outflow, that is the parallel decrease of cutaneous and cardiac sympathetic activities, and the converse increase of splanchnic activity. Therefore, Flavoxate hydrochloride is thought to have an effect on the integrating mechanism of the sympathetic nervous system. This view was also supported by the experiments with neuromuscular preparation of lobster (<I>Panulirus japonicus</I>).<BR>It is concluded from these results, that the change of gastrointestinal motility induced by intravenous injection of Flavoxate hydrochloride (10 mg/kg) is influenced both by its effect on the gastrointestinal smooth muscle itself and by its effect <I>via</I> the autonomic nervous system.

著者

• 土屋 勝彦

  東京都老人研究所・第一生理

• 入来 正躬

  東京都老人研・第一生理

• 大幡 勝也

  日本新薬総合研究所

• 野村 彰

  日本新薬総合研究所

• 入来 正躬

  東京都老人総合研究所生理学部

• 古沢 恵美

  東京都老人総合研究所生理学部

• 蔵本 武照

  教育大学理学部動物学教室

• 三浦 朗

  日本新薬総合研究所

• 土屋 勝彦

  東京都老人総合研究所生理学部

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