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In the present study, the effects of prostaglandin I<SUB>2</SUB> (PGI<SUB>2</SUB>) on the vasoconstrictor response to adrenergic nerve relating agents was examined using the perfused arterial preparations, i.e., the isolated perfused central artery of a rabbit ear and its perfused arterial segment. The following results were obtained.<BR>1. PGI<SUB>2</SUB>, 3.0 to 9.0ng/m/, slightly enhanced not only the vasoconstrictor response to electrical stimulation of the perivascular sympathetic nerve (VSNS), and that to the exogenously applied noradrenaline, but also the noradrenaline-induced contracture.<BR>2. In the experiment examining the effect of VSNS on 6-keto-PGF<SUB>1α</SUB>, a main metabolite of PGI<SUB>2</SUB>, levels in the effluent perfusate, it was clarified that 6-keto-PGF<SUB>1α</SUB> levels following VSNS were lower than those before VSNS.<BR>These results seem to suggest that PGI<SUB>2</SUB> is a weak vasoconstrictor in a rabbit ear and the endothelium of vascular wall would be inclined to be damaged by the mobilization of an adrenergic nerve transmitter.
- 日本平滑筋学会の論文
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