子宮筋収縮機構におよぼす高濃度estrogen progesteroneの作用

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1. The effects of a high concentrated estrogen and progesterone were studied on the contractile activities in isolated myometrial strips from humans and rats by recording isometric tension development. The contractions were reduced by 10-5-3×10-5 M estrone (E1), estradiol (E2), estriol (E3), and progesterone (P) in non pregnant human uterus. The contractions were reduced by 10-6-10-4 M E1, E2, E3 and P in non pregnant rat uterus. The contractions induced by 10-8-10-5 M PGE2 and PGF2a were reduced by 10-5 M E2 and P in non pregnant rat uterus. The contractions induced by 10-10 -3×10-8 M oxytocin were reduced by 10-5 M E2 and P in non pregnant rat uterus. The contractures induced by 10-4-10-2 M Ca2+ were reduced by 10-5 M E2 and P in non pregnant rat uterus. 2. The effects of a high concentrated estrogen and progesterone were studied on Ca2+influx and Ca2+ release from intracellular Ca store in the depolarized uterine smooth muscle cells from non pregnant rats. The inhibitory effects on the contractility by 3×10-6-3×10-5M E2, E3 and P supported the suggestion that estrogen and progesterone have an inhibitory action on Ca2+ influx and Ca2+ release from intracellular Ca store.
日本平滑筋学会の論文