Low-sodium resistant non-adrenergic inhibitory neurotransmission in the guinea-pig duodenum.
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Ohkawa, H. <I>Low-sodium resistant non-adrenergic inhibitory neurotransmission in the guinea-pig duodenum. Japanese Journal of Smooth Muscle Research</I>, 22 (1), 1-10. -The evoked inhibitory potentials (i.p.s) in the longitudinal smooth muscle cells of theguinea-pig duodenum were recorded intracellularly. The i.p.s were not blocked by adrenergic blocking agents, guanethidine (10<SUP>-6</SUP>g/m<I>l</I>), propranolol (10<SUP>-6</SUP>g/m<I>l</I>) and phentolamine (10<SUP>-6</SUP>g/m<I>l</I>), and atropine (10<SUP>-6</SUP>g/m<I>l</I>). Tetrodotoxin (10<SUP>-7</SUP>-10<SUP>-6</SUP>g/m<I>l</I>) abolished the nonadrenergic noncholinergic i.p.s evoked by single or repeated stimulation without changes in the resting membrane potential of the longitudinal smooth muscle. In the presence of atropine (10<SUP>-6</SUP>g/m<I>l</I>), acetylcholine (5×10<SUP>-9</SUP>-7×10<SUP>-7</SUP>g/m<I>l</I>) had no effect on the amplitude of the i.p.s dtubocurarine (2×10<SUP>-5</SUP>g/m<I>l</I>) reduced the amplitude of the i.p.s and produced a small depolarization in the muscle membrane. The longitudinal muscle membrane was slightly depolarized by Li-solution and the i.p.s could be evoked in the Li-solution for a long period, accompanying with the slight decrease in the amplitude of the i.p.s. In the choline-solution, the depolarization of the muscle membrane and the slight increase in the amplitude of the i.p.s were obtained. The i.p.s were abolished in the Ca<SUP>2+</SUP>-free choline-solution. In the sucrose-solution, the decrease of the resting membrane potential of the longitudinal smooth muscle was observed and the amplitude of the i.p.s wasgradually reduced during the perfusion of the sucrose-solution. Chloride deficiency had no considerable effect on the amplitude of i.p.s.<BR>The results obtained suggest that the non-adrenergic non-cholinergic inhibitory neurotransmission is low-sodium resistant and the excitation-secretion coupling in the nonadrenergic non-cholinergic inhibitory nerves is mainly dependent on the external calcium ions but not sodium ions.
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- Low-sodium resistant non-adrenergic inhibitory neurotransmission in the guinea-pig duodenum.
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