ELECTRON MICROSCOPIC STUDIES ON THE INNERVATION OF THE DEVELOPING HUMAN INTESTINAL SMOOTH MUSCLE
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概要
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The developmental morphology of the neuro-muscular junction in the small intestine of the human fetuses from 8 weeks to 20 weeks has been studied with the electron microscope. In the 8th week embryos, neural processes from Auerbach's plexus were found to have extended to the surface of the muscle cells, which appeared as a thin layer on the inside of the plexus. The neural processes found on the surface of the muscle cells contained occasionally a numbr of small vesicles of irregular form and fine filaments. In the tenth and eleventh weeks, when the logitudinal muscle layer was formed on the outside of Auerbach's plexus, the neural processes were demonstrated to have extended into the circular muscle layer. They, hawever, were still free and did not form bundle with Schwann cell cytoplasm. In the muscle lyer of 14 weeks old fetus, many bundles of the nerve fibers were observed accompanying Schwann cell process and the cells with light cytoplasm. The latter cells may be considered as Cajal's interstitial cell. The neural processes which were terminated on the muscle cell surface appeared to have, whithing the processes, many small vesicles of 300 to 500 A in diameter and a number of cored vesicles of 1000 A in size. In 20 weeks old fetus, the nerve bundles in the muscle layer increased both in number and size. The neural processes which were terminated on the muscle cell surface contained many vesicles and cored vesicles. The small vesicles appeared sometimes in a cluster in the vicinity of the axoplasmic membrane. The thickening of the presynaptic membrane was found inconstantly in the present observation.
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