RELAXANT EFFECT OF ADENOSINE TRIPHOSPHATE AND ITS RELATED NUCLEOTIDES ON THE GUINEA-PIG TAENIA COLT

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概要

• 論文の詳細を見る

• Pharmacological analysis was made on the relaxant effect of ATP and its related nucleotides to guinea-pig taenia coli . ATP and ADP were equally the most potent among the compounds tested in causing relaxation of the taenia . The relaxant responses to these compounds had rapid onsets as that to electrical stimulation of the intrinsic non-adrenergic inhibitory nerves . The relaxant effect of ATP (10<SUP>-6</SUP>-10<SUP>-5</SUP>g/ml) was completely prevented by either imidazole (3.5×times;10<SUP>-3</SUP>g/ml) or phentolamine (5×times;10<SUP>-6</SUP>g/ml), though the relaxation due to stimulation of the intrinsic inhibitory nerves was not influenced by these blocking agents. These results are rather against the concept that ATP or its related nucleotide is the transmitter substance of the intrinsic non-adrenergic inhibitory nerves.

• 日本平滑筋学会の論文

著者

• 鈴木 恒彦

  東北大学医学部応用生理学教室

• 力丸 陽

  東北大学医学部応用生理学教室

• 福士 靖江

  東北大学医学部応用生理学教室

関連論文

• STUDIES ON THE REGULATORY MECHANISM OF PERISTALSIS IN THE ISOLATED DOG URETER
• RELAXANT EFFECT OF ADENOSINE TRIPHOSPHATE AND ITS RELATED NUCLEOTIDES ON THE GUINEA-PIG TAENIA COLT
• INNERVATION OF THE SMOOTH MUSCLE OF THE GUINEA-PIG TRACHEA

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