THE EFFECT OF THE INTRINSIC MUCOSAL REFLEX UPON THE MOTILITY OF THE INTERNAL ANAL SPHINCTER.

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概要

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• Effects of distention of the caudal end of the distal colon on the internal anal sphincter were studied with the balloon-water manometer method in anesthetized dogs.<BR>Distention of the distal colon (40-130 mmHg) induced relaxation of the internal anal sphincter. After severing the external nervous supply or pithing the spinal cord below the 11 th thoracic segment, the sphincteric relaxation also occurred. The same response was elicited by chemical (gallic juice), mechanical (stroking with a clot of cotton-wool), or electrical stimulation to the colonic mucosa. After intravenous administration of tetrodotoxin or C<SUB>6</SUB>, the response was abolished.<BR>It may be concluded that the response is chiefly due to the mucosal intrinsic reflex via the ganglion cells in the intramural plexus (Auerbach's plexus) and that the mucosal intrinsic reflex will contribute to the defecation reflex.

• 日本平滑筋学会の論文

著者

• 渡邊 克仁

  岡山大学医学部第二生理学教室

関連論文

• THE EFFECT OF THE INTRINSIC MUCOSAL REFLEX UPON THE MOTILITY OF THE INTERNAL ANAL SPHINCTER.

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