AN INEXPENSIVE VACUUM FORMED VENTRICULAR ASSIST DEVICE

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概要

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• Abstract: We have developed a pneumatically driven, pulsatile 20mL. ventricular assist device(VAD), designed to be driven using a widely distributed IABP driver. All parts of the VAD(Fig.1)including the integrated valves, housing and base were fabricated from Pellethane a biocompatible polyurethane(PU), using the vacuum forming process. The fabrication process was assesed for variations in performance of individual VADs in terms of hydrodynamics, especially in the valves. The fabrication of valves using the vacuum forming process as well as solution casting were assessed using a commercially available Bjork-Shiley Monostrut(BS)valve for comparison. The leakage rate for the valves produced by the vac. forming resulted in a rate one-fifth that of the BS valve. However, the forward flow resistance which was ten times greater than the BS valve, did not adversley effect the functioning of the PU valve. A comparison with PU valves(Fig.2)made using solution casting resulted in a leakage rate of 83-285ml/min as compared to79-109ml/min for the vac. formed valves. The VAD fabricated by vacuum forming produced a mean flow rate of approx. 2L/min(Fig.3)with only minor variations in performance, at a drive pressure of 180mmHg, vacuum of -20mmHg and under an afterload of 90mmHg. The VAD has also been trialed in chronic animal experiments to assess its' hemodynamic characteristics. The VAD was implanted in left and right heart configurations in sheep and goats for periods up to 1 month, resulting in low blood hemolysis with little evidence of thrombosis. From these results it was evident that it was possible to control the quality of an inexpensive VAD using the vacuum forming technique.

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著者

• Umezu M.

  Waseda University, Dept. of Mechanical Engineering.

• Ranawake M.

  Waseda University, Dept. of Mechanical Engineering.

• Shimasaki Y.

  Waseda University, Dept. of Mechanical Engineering.

• Ohnuma T.

  Waseda University, Dept. of Mechanical Engineering.

• Moribe T.

  Waseda University, Dept. of Mechanical Engineering.

• Nojiri C.

  Terumo Corp. R&D Centre .

• Kijima T.

  Terumo Corp. R&D Centre .

• Kido T.

  Terumo Corp. R&D Centre .

• Kijima T.

  Terumo Corp. R&D Centre .

関連論文

• AN INEXPENSIVE VACUUM FORMED VENTRICULAR ASSIST DEVICE

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