高血圧家族歴を有する青年期女子における赤血球膜中の脂質とNa-K ATPase関連について〔英文〕

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Numerous studies and reports have investigated an important role of lipid in the erythrocyte membrane. About 50% of the lipid composition of erythrocyte membrane consists of phospholipid, 40% is unesterified cholesterol, and 10% is glycolipid. The modified lipid composition of erythrocyte membrane influences the activity of membranebound enzyme like Na-K ATPase (Anner, 1985; Cooper et al., 1983; Incerpi et al., 1983; Marcus et al., 1986; Yeagle, 1983). The relationship between Na-K ATPase activity and hypertension has been investigated (Swarts et al., 1981; Walter, 1982; Wambach et al., 1982; Wocial et al., 1984), since Garay and Meyer (1979) published their observations and estimated the positive association between sodium-potassium cotransport and hypertension. Recently an inhibitor of Na-K ATPase was found in hypertensives, and low activity of Na-K ATPase points to a possible association with essential hypertension (Hamlyn et al., 1982; Hugues et al., 1984; MacGreygor et al., 1980). We have, therefore, investigated the relationship between membrane lipids and Na-K ATPase activity using erythrocyte membranes from normotensive adolescents grouped according to a family history of hypertension.
日本民族衛生学会の論文