Long-lasting Increase of Regional cAMP and cGMP in Amygdaloid Kindled Rat Brain
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There is increasing evidence that cyclic adenosine 3', 5'-monophosphate (cAMP) and cyclic guanosine 3', 5'-monophosphate (cGMP) have important roles in the pathophysiological mechanisms of epileptic seizures. However, the relationship between persistent epileptogenesis and cyclic nucleotides systems in neural tissue has not been well studied.<BR>The present study, therefore, was performed to examined the hypothesis that kindling itself might produce a long-lasting increase of both nucleotides in the brain, since this could be one mechanism of persistent epileptogenesis. Stimulations (300μa, 50 Hz, 1 sec, twice each day) were delivered to the left amygdala until a full convulsion was achieved on 5 consecutive stimulations. Thirty days after the last stimulation the animals were sacrificed by microwave irradiation.<BR>The concentrations of cAMP and cGMP were measured by radioimmunoassay methods. The concentrations of cAMP had increased remarkably in the right hippocampus (P<0.05) and both occipital cerebral cortices (P<0.02) in kindled animals. In the left amygdala, which had been stimulated, the concentrations of cAMP increased but not significantly (P<0.1). The concentrations of cGMP in the kindled animals increased significantly in the stimulated left amygdala (P<0.05), as well as in both hippocampi (left P<0.05, right P<0.001) and both occipital cerebral cortices (P<0.02).<BR>These data suggest that the persistent regional excitability, which may be associated with synaptic potentiation, produced by kindling may be attributed to a longlasting regional increase of both cyclic nucleotides.
- 一般社団法人 日本てんかん学会の論文
一般社団法人 日本てんかん学会 | 論文
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