Effect of Parenteral Pentylenetetrazol on Amygdaloid and Frontal Cortical Kindling in Cats
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概要
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Daily repetitive electrical stimulations to a distinct site of the animal brain result in a progfessive augumentation in neuronic excitability and a lowering of seizure threshold (the. kindling phenomenon). Recent studies have disclosed that the constitutional or aquired convulsive predisposition plays a significant role to modulate the evolution of clinico-electrographic seizure events. In this study a series of long term experiments were designed to determine the effect of parenteral administration of pentylenetetrazol (PTZ) prior to the daily stimulation as a strategy of producing a convulsion-prone condition in cats.<BR>Fourteen cats used were devided into the amygdaloid kindling group (7 cats) and the frontal-cortical kindling group (7 cats); the seven cats of each group were further devided into a control group (3 cats) and a PTZ group (4 cats). The individually determined subconvulsive threshold dosage of PTZ (Range: 14-25mg/kg with a mean of 17.9±SD 3.0) was intramuscularly injected every day immediately before electrical stimulation.<BR>The PTZ group of both the amygdaloid and frontal cortical kindling showed a distinct facilitation of clinico-electrographic seizure developments in comparison with the control group. In addition to the facilitation of kindling stages shown by the PTZ groups, the acceleration of interictal epileptic discharges in time and space which closely correlate with secondarily established neuronic hyper-excitability were also exemplified in the PTZ groups of both the amygdaloid and frontal animals.
- 一般社団法人 日本てんかん学会の論文
一般社団法人 日本てんかん学会 | 論文
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