1歳未満発症のけいれん性疾患の長期予後一発作型を中心として一

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Clinical aspects, long-term prognosis, and the evolution of seizure. types were studied in 304 cases with convulsive disorders in the first year of life. All patients except 45 dead cases were followed until six years of age or older. Seizures during the first year were divided into 5 types according to the clinical features of seizures and the interictal. EEG: 1) unclassified generalized motor seizures (GMS), 2) infantile spasms (IS), 3) seizures belonging to secondary generalized epilepsy other than infantile spasms (SGE), 4) partial seizures (PS), 5) hemiconvulsive seizures (HCS). In patients with GMS during the first year, the prognosis for mental and physical development was the most excellent, and seizures stopped before 3 years of age in most of them. The high incidence of family history of convulsive disorders in them indicates that some genetic factors might be involved in the etiology of GMS. In patients with IS or other SGE, delayed development or neurological abnormality before the onset of seizures were more frequently seen, and the prognosis was the most unfavourable. In patients with PS, the prognosis for mental and physical development and seizures were intermediate between the above two.
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