Long-term Follow-up Study of West Syndrome:Seizure Types and EEG Findings at Age 5-10 Years

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Clinical seizure types and EEG findings at age 5-10 years were studied on 162 patients of West syndrome seen between 1963 and 1974. Patients were divided into five groups according to their latest physical and mental status: normal, only physical disability, only mental disability, mild to moderate physical and mental disabilities, and severe physical and mental disabilities. At ages from 5 to 7 and from 8 to 10, seizure types were analyzed on the basis of international classification of epileptic seizures, and EEG findings were divided into five groups: normal, focal seizure discharges, generalized seizure discharges, hypsarrhythmia, and other abnormalities. Only 12% of patients showed normal physical and mental development, and 33% showed only mental disability, and 34% had severe physical and mental disabilities. Throughout all ages, one-third of patients had no seizures at least one previousyear. About 80% of patients who still had seizures experienced generalized seizures, especially tonic seizures which represented more than 80% of them. Throughout all ages, about 10% of patients showed normal EEGs, and focal and generalized seizure discharges were almost equally distributed among the patients. No seizures and normal EEGs were associated with normal development. Patients who had generalized seizures showed a higher percentage of physical and mental disabilities.
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